Journal Club: Exploring breakthroughs in multiple sclerosis bladder health treatment with noninvasive brain Stimulation Artwork

Bladder Buzz Podcast

The Rehabilitation Research and Training Center on Neurogenic Lower Urinary TractDysfunction (NLUTD) was launched in 2019 and includes a diverse team of physicians(rehabilitation, urology, pediatrics), researchers, and people with NLUTD (more commonlyknown as “neurogenic bladder”). We are located across the United States and have a passion to advance science, health care, and quality of life around this common condition. Our podcasts are for clinicians, scientists, non-scientists, adults, kids, and everyone in between. We cover a wide range of topics, from the basics of neurogenic bladder and its management, to being in a relationship and dating, social justice, and even how your bladder is like a snowflake! So, if urine need of some of the latest knowledge on neurogenic bladder from experts in the field, then urine luck!

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Bladder Buzz Podcast

Journal Club: Exploring breakthroughs in multiple sclerosis bladder health treatment with noninvasive brain Stimulation

June 11, 2024 • RRTC on Neurogenic Bladder • Season 4 • Episode 5

Bladder symptoms are extremely common in individuals with MS. These symptoms include urinary frequency, urgency, incontinence or difficulty voiding or both. Voiding dysfunction (VD), a common neurogenic lower urinary tract symptom in individuals with multiple sclerosis (MS), often leads to urinary retention. The current primary management for MS patients with VD involves catheterization. Our team has explored the safety and therapeutic effects of a multi focal transcranial magnetic stimulator, a noninvasive, portable neuromodulator capable of simultaneously stimulating or inhibiting multiple brian regions and modulating the strength of their functional connections called Transcranial Rotating Permanent Magnet Stimulator (TRPMS).

In this study, MS women with VD underwent functional magnetic resonance imaging concurrently with a urodynamic study (fMRI/UDS) before and after ten 40-minute TRPMS sessions. Baseline fMRI/UDS scans identified regions of interest (ROIs) associated with voiding initiation, guiding microstimulator placement. Post-treatment, patients exhibited increased activation in these ROIs, a significant decrease in % post-void residual/bladder capacity (%PVR/BC), and reported improved bladder symptoms including more effective bladder emptying.

Individuals seeking further information visit khavariresearch.com, reach out via email at msbladder@houstonmethodist.org, or locate details on clinicaltrials.gov where it is registered.